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英国应用光物理公司上海代表处
制药/生物工程|外商独资/代表处|1-49人
英国应用光物理公司上海代表处
公司介绍
英国应用光物理公司 Applied Photophysics Ltd 成立于1971年, 发起人是 1967年诺贝尔化学奖获得者 George Porter 教授,是世界知名的专业仪器制造商, 圆二色CD光谱仪、停流stopped flow 反应动力学分析仪分析仪等广泛应用于分子结构、分子间相互作用、动力学分析等领域的研究,特别是生物大分子、生物大分子与小分子如药物、各类手性化合物等的结构与相互作用的研究。

Chirascan 系列圆二色CD光谱仪为静态圆二色光谱分析树立了新的标准,采用多种新技术、新设计, 在圆二色检测的精确度、准确度等方面相比传统圆二色仪器都有了革命性的提高, 从而大大扩展了圆二色光谱CD方法的应用, 特别是在生物制药行业的高级结构表征、高级结构相似性比较的研究,配套符合FDA行业指南的数据统计学分析方法及软件,便于业内科研人员确认对数据的信心及出具对外申报的数据结果。
Chirascan系列型号的CD光谱仪, 用户遍布各大高校和研究所的一流实验室, 如清华大学 (目前6台)、北京大学(2台)、中山大学3台, 四川大学(3台)、中科院生物物理所(蛋白质平台) 、 中科院微生物所(3台) 中科院上海药物所、中科院上海有机所、中科院上海生化细胞所等, 以及知名制药公司如Pfizer,BMS,GSK, AstraZeneca, NovoNordisk、Eli Lilly ,Roche ,Amgen等, 以及上海药明康德、上海中科新生命、上海复宏汉霖、上海恒瑞制药、神州细胞生物工程公司、百济神州(苏州)、上海君实药业、山东新时代药业等。
随着生物制药行业的发展和分析检测的新需求的出现, 英国应用光物理公司 Applied Photophysics 的子公司Protein Stable 推出了蛋白质化学稳定性分析解决方案 SUPR-CM ,用于分析蛋白质的化学稳定性 (如理解蛋白质的去折叠过程和机制), 筛选合适的蛋白质浓度,从而更快地筛选formulation或者药物候选体筛选,检测手段是荧光法, 区别于市场上的其它方式的是 快速( 384孔板, 2.5分钟扫描一块板)、自动化、高通量 ,高灵敏度高质量的数据(CCD 荧光检测), 可以设置 任意incubation 时间如24小时, 48小时, 甚至更长(不同于目前市场上局限于2.5小时内等).
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上海市恒丰路218号 , 邮编 200070 Applied Photophysics is a world leading manufacturer and supplier of precision spectrometers for the study of circular dichroism, stopped flow kinetics and laser flash photolysis. The company supplies the life sciences community in both academic and commercial spheres with instruments that are used to study the structural, thermodynamic and kinetic properties in solution of a wide range of samples. The current main product range comprises the Chirascan circular dichroism spectrometer, the SX20 stopped flow spectrometer and the LKS.60 laser flash photolysis spectrometer. The products from Applied Photophysics are designed to study a wide range of molecules and are widely used in research and pharmaceutical applications. The product portfolio includes three main technology platforms: Circular Dichroism (CD) spectroscopy that is used primarily for looking at protein secondary & tertiary structure, protein folding and the stability of proteins in different environments; this has been widely adopted in many applications in the fields of biophysical and biochemistry research. Circular dichroism is also widely used in the Pharmaceutical industry particularly in biotherapeutic drug development to optimize formulations and understand protein structure and stability. Additionally the technique has also been used in pharmacokinetics to study in vitro the potential interactions of small molecule drugs. Applied Photophysics' Chirascan is the most advanced circular dichroism spectrometer available today. It is particularly valuable in elucidating the higher structures of bio macromolecules in solution, for example the secondary structures of proteins, DNA and RNA, and how these structures change when stressed by temperature, pH or other means such as drug binding. Stopped flow technology is extensively used to study biomolecular interactions, kinetics and fast reaction mechanisms typical of many reactions in chemical and biological systems. This technology has been widely adopted and is a powerful tool for analysis of mechanisms of a great variety of chemical and biochemical phenomena. Laser flash technology is used to measure extremely fast reaction mechanisms, typically of transient species such as radicals, excited states or ions. This highly specialised technique allows probing of some of the fastest chemical processes, and consequently has been used extensively to research these phenomena. Applied Photophysics Limited was established in 1971 by The Royal Institution of Great Britain. For more information, please visit http://www.photophysics.com/·想学车,就拨114,全包3600元起
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