职责描述：
We are currently seeking a highly experienced and talented individual with strong chemistry background and a proven track record in the early product development of Antibody Drug Conjugates (ADCs). The successful candidate will report directly to the department head and will have the opportunity to utilize their ADC development proficiency to contribute to the advancement of company’s pipeline. Moreover, the candidate is expected to broaden the scope of work to a more diverse spectrum of product, such as targeted nanoparticles, antibody-cell conjugates, and antibody-oligonucleotide conjugates etc.,

1. Keep abreast of current understanding of ADC development and provide expert opinions in ADC research platform, including antibody selection/engineering, linker-payload selection/optimization, conjugation methods, analytical assessments and assay development;
2. Stay up-to-date with emerging technologies and scientific advancements in bioconjugation, proactively identify opportunities for innovation and improvement, and implement pioneering methodologies into internal projects;
3. Design and perform experiments to evaluate the pharmacological properties of ADC/XXC products. Investigate the efficacy and safety of ADC/XXCs, assess their mechanisms of action, and contribute to the understanding of factors influencing drug response;
4. Collaborate with multidisciplinary teams, including medicinal chemistry, pharmacology, toxicology, and manufacturing, to ensure smooth progression of projects and adherence to project timelines;
5. Mentor junior staff with scientific guidance and professional support;
6. Contribute to the development of Standard Operating Procedures (SOPs), assist in patent application and participate in the composition of scientific manuscript.

任职要求：
1. A Ph.D. degree in chemistry and a good grasp of organic chemistry, in particular synthetic organic chemistry, complemented by 5+ years related technical and managerial experience in renowned CRO or pharmaceutical companies;
2. Strong background and outstanding record of accomplishments in ADC early product development;
3. Successfully managing teams in the development of complex biopharmaceutical products such as targeted nanoparticles, antibody-cell conjugates, and antibody-oligonucleotide conjugates is highly desirable;
4. Practical experience in the early development of ADC and XXC drugs, such as bioconjugation, characterization, scale-up, and formulation is highly regarded;

其他信息
语言要求：英语、普通话

所属部门：SHIC