JOB DESCRIPTION:
We are seeking an exceptional senior scientist to join the pre-clinical pharmacology team in Translational Science. The primary focus of the department is to translate newly discovered biological targets and pioneering therapeutics using preclinical models to inform human disease for candidate selection and progression to clinical trials. The ideal candidate will oversee and manage the preclinical pharmacology laboratory, including experimental protocol design and execution. The individual in this position will be responsible for managing the laboratory of 5-7 junior scientists while designing, conducting, and analyzing in vitro and in vivo experiments employing various experimental approaches. Additionally, as the head laboratory manager, the individual will be responsible for instituting appropriate protocols, laboratory safety, and SOPs, while maintaining meticulous data documentation (including oversight of team member notebooks, and data organization and storage), instrumentation and supplies. Our research areas comprise, but are not limited to, new drug discovery and development for severe musculoskeletal disorders such as osteoporosis, osteogenesis imperfecta and other disorders related to bone, cartilage and muscle. An ideal candidate is a seasoned scientist who has spent a considerable amount of training in the musculoskeletal field, has extensive experience in molecular and cell biology techniques, as well as expertise in utilizing various animal models of human disease.

JOB RESPONSIBILITIES:
1. Supervises work of lab team, including planning, assigning and scheduling work, reviewing work and ensuring quality data standards, training staff and overseeing their productivity. May offer recommendations for hiring, termination and pay adjustments.
2. Maintains laboratory productivity by monitoring the workload of functional areas.
3. Designs, plans, oversees (as well as independently performs when needed) in-vivo experiments using small and larger animal models to dissect complex molecular phenotypes associated with human disease findings in musculoskeletal disease field.
4. Independently analyzes molecular and functional characterization of disease variants associated with disease phenotypes.
5. Designs and tests the biology of novel molecules in specific in-vitro and/or ex-vivo cell-based systems.
6. Implement new programs, tests, methods, and instrumentation.
7. Identifies informational needs to manage laboratory information systems.
8. Establishes quality standards to maintain laboratory safety protocols, SOPs and laboratory equipment use and performance.
9. Oversee laboratory expenses and costs, while keeping supplies stocked by determining inventory level.
10. Meets during weekly lab meetings with other technical personal to ensure all labs procedures and equipment working well and there is no need for improvements.
11. Prepares and presents study reports and data analyses.
12. Draft regulatory documents in support of drug development.
13. Prepare manuscripts for scientific publications.
14. Collaborate with cross functional teams across the company as well as external CROs that support the drug development pipeline.

QUALIFICATIONS:
1. PhD or equivalent degree in the field of biomedical science (biochemistry, physiology, and pharmacology, etc.) and a minimum of 4 years of research experience in musculoskeletal disease area with good track record of scientific presentations and publications.
2. Demonstrated experience in in vivo studies, proficient with microscopy/histology tissue process and analysis.
3. Hands-on experience in molecular and cellular biology techniques including QPCR, Western Blot, cell culture, ELISA, and more.
4. Demonstrated ability to troubleshoot and solve complex problems.
5. Demonstrated management skills that include training and oversight of junior researchers
6. Ability to manage a heavy workload, demands on time and resources and prioritize effectively.
7. Effective oral, written, communication skills are required.
8. Fluency in English and Chinese
9. Able to excel in a fast-track environment while requiring multitask across multiple projects.

其他信息
语言要求：英语、普通话
行业要求：全部行业
所属部门：转化医学-非临床药理